- Original Article
- Pulmonology
- Increased procalcitonin level is a risk factor for prolonged fever in children with Mycoplasma pneumonia
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Ji Eun Jeong, Ji Eun Soh, Ji Hee Kwak, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Moon Soo Park, Jung Yeon Shim
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Clin Exp Pediatr. 2018;61(8):258-263. Published online August 15, 2018
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Purpose: Macrolide-resistant Mycoplasma pneumoniae pneumonia (MPP) is characterized by prolonged fever and radiological progression despite macrolide treatment. Few studies have examined serum procalcitonin (PCT) level in children with MPP. We aimed to investigate the association of acute inflammation markers including PCT with clinical parameters in children with MPP. Methods: A total of 147 children were recruited. The diagnosis of MPP... |
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- Case Report
- Case of seropositive allergic bronchopulmonary aspergillosis in a 10-year-old girl without previously documented asthma
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Jeong Eun Shin, Jae Won Shim, Deok Soo Kim, Hae Lim Jung, Moon Soo Park, Jung Yeon Shim
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Clin Exp Pediatr. 2015;58(5):190-193. Published online May 22, 2015
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Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease due to bronchial colonization of Aspergillus fumigatus that occurs in susceptible patients with asthma or cystic fibrosis. A 10-year-old girl was referred to the Department of Pediatric Pulmonology for persistent consolidations on chest radiography. Pulmonary consolidations were observed in the right upper and left lower lobes and were not resolved with... |
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- Original Article
- Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels, and the severity of atopic dermatitis in children
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Bo Ram Cheon, Jeong Eun Shin, Yun Ji Kim, Jae Won Shim, Deok Soo Kim, Hye Lim Jung, Moon Soo Park, Jung Yeon Shim
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Clin Exp Pediatr. 2015;58(3):96-101. Published online March 20, 2015
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Purpose Atopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD. The aim of our study was to determine whether 25-hydroxyvitamin D (25(OH)D) levels are related to IL-31 levels or to the severity of AD. MethodsWe enrolled 91... |
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- Increased risk of refractory Mycoplasma pneumoniae pneumonia in children with atopic sensitization and asthma
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Jeong Eun Shin, Bo Ram Cheon, Jae Won Shim, Deok Soo Kim, Hae Lim Jung, Moon Soo Park, Jung Yeon Shim
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Clin Exp Pediatr. 2014;57(6):271-277. Published online June 30, 2014
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Purpose A nationwide outbreak of Mycoplasma pneumoniae pneumonia (MP) refractory to macrolide antibiotics occurred in Korea during 2011. Steroid therapy has been reported to be both efficacious and well tolerated in pediatric patients with refractory MP. We compared clinical features and laboratory characteristics between children with refractory MP requiring steroid treatment and those with macrolide-responsive MP and evaluated the risk factors... |
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- Case Report
- Klebsiella pneumoniae liver abscess in an immunocompetent child
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Jang-Mi Kwon, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Jung Yeon Shim, Moon Soo Park
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Clin Exp Pediatr. 2013;56(9):407-410. Published online September 30, 2013
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Klebsiella pneumoniae has emerged as a leading pathogen that causes pyogenic liver abscesses (PLAs) in Korea. K. pneumoniae liver abscess (KLA) is potentially life threatening, and the diagnosis is difficult. In developed countries, PLA is rarely observed in children and is frequently associated with disorders of granulocyte function and previous abdominal infection. We observed a case of KLA in a... |
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- Original Article
- Expression of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ in the lung tissue of obese mice and the effect of rosiglitazone on proinflammatory cytokine expressions in the lung tissue
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Seung Lok Ryu, Jae Won Shim, Duk Soo Kim, Hye Lim Jung, Moon Soo Park, Soo-Hee Park, Jinmi Lee, Won-Young Lee, Jung Yeon Shim
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Clin Exp Pediatr. 2013;56(4):151-158. Published online April 22, 2013
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Purpose We investigated the mRNA levels of peroxisome proliferator-activated receptor (PPAR)-α, PPAR-γ, adipokines, and cytokines in the lung tissue of lean and obese mice with and without ovalbumin (OVA) challenge, and the effect of rosiglitazone, a PPAR-γ agonist. MethodsWe developed 6 mice models: OVA-challenged lean mice with and without rosiglitazone; obese mice with and without rosiglitazone; and OVA-challenged obese mice with and... |
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- Successful and safe treatment of hemangioma with oral propranolol in a single institution
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Sun Hee Chung, Dong Hyuk Park, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Jung Yeon Shim, Moon Soo Park, Hong Hoe Koo
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Clin Exp Pediatr. 2012;55(5):164-170. Published online May 21, 2012
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Purpose Dramatic improvement of hemangioma to propranolol has been recently reported; however, details on dose and duration of treatment, potential risks, and monitoring have not been determined. The objective of this study is to describe and analyze the use of propranolol as a first-line treatment or as a single therapy in management of complicated hemangioma. MethodsA retrospective chart review of eight patients... |
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- Transforming growth factor-β promoted vascular endothelial growth factor release by human lung fibroblasts
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Sang Uk Park, Joo Hwa Shin, Jae Won Shim, Deok Soo Kim, Hye Lim Jung, Moon Soo Park, Jung Yeon Shim
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Clin Exp Pediatr. 2008;51(8):879-885. Published online August 15, 2008
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Purpose : The human lung fibroblast may act as an immunomodulatory cell by providing pro-inflammatory cytokines and chemokines, which are important in airway remodeling. Vascular endothelial growth factor (VEGF) induces mucosal edema and angiogenesis. Thymus and activation regulated chemokine (TARC) induces selective migration of T helper 2 cells. We investigated whether human lung fibroblasts produced VEGF and TARC, and the... |
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- Case Report
- A case of idiopathic renal hypouricemia
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Moon Hee Han, Sang Uk Park, Deok-Soo Kim, Jae Won Shim, Jung Yeon Shim, Hye Lym Jung, Moon Soo Park
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Clin Exp Pediatr. 2007;50(5):489-492. Published online May 15, 2007
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Idiopathic renal hypouricemia is a disorder characterized by impaired urate handling in the renal tubules. This disease usually produces no symptoms, but hematuria, uric acid nephrolithiasis or acute renal failure may develop. A defect in the SLC22A12 gene, which encodes the human urate transporter, is the known major cause of this disorder. We describe a 10-month-old boy with idiopathic renal... |
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- Original Article
- Clinical features of congenital muscular torticollis
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Ji Eun Jun, Hye Kyeong Ryu, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-Soo Kim
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Clin Exp Pediatr. 2007;50(3):241-247. Published online March 15, 2007
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Purpose : Congenital muscular torticollis (CMT) is a common and benign congenital disorder of the musculoskeletal system in neonates and infants. The pathophysiology is that the sternocleidomastoid muscle (SCM) is shortened on the involved side by fibrosis, leading to ipsilateral tilt and contralateral rotation of the face and chin. In this study, we investigated the clinical features of CMT, the... |
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- Improved survival rate with decreased neurodevelopmental disability in extreme immaturity
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Ga Won Jeon, Myo Jing Kim, Sung Shin Kim, Jae Won Shim, Yun Sil Chang, Won Soon Park, Mun Hyang Lee
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Clin Exp Pediatr. 2007;50(11):1067-1071. Published online November 15, 2007
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Purpose : The aim of this study was to determine whether improved survival of extremely low birth weight infants (ELBWI) was associated with decreased neurodevelopmental disability later in life, and also to identify the factors influencing this disability.
Methods : ELBWI admitted to the neonatal intensive care unit of Samsung Medical Center, survived, and followed up until the corrected age... |
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- Relationship of serum IL-13 and eotaxin level with airway hyperresponsiveness in children with asthma
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Eun Young Park, Jung Yeon Shim, Myung Hwan Yoo, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
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Clin Exp Pediatr. 2006;49(8):889-894. Published online August 15, 2006
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Purpose : Asthma is characterized by the presence of airway hyperresponsiveness(AHR) and inflammation. The extensive eosinophil infiltration into the lung is the hallmark of asthma and contributes to the damage of respiratory epithelium during late phase airway responses. Eotaxin is the major eosinophil chemoattractant found in bronchoalveolar lavage(BAL) fluid of allergic inflammation. IL-13 has been known to induce the... |
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- A study of neuropeptides related to headaches in children with meningeal irritation signs
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Bo Gil Seo, Myung Hwan Yoo, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-Soo Kim
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Clin Exp Pediatr. 2006;49(5):533-538. Published online May 15, 2006
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Purpose : The headache, one of the symptoms of meningitis, is related to abrupt elevation of intracranial pressure(ICP) or stimulation of intracranial nociceptive structure. However, in cases of mild elevation of ICP or normal findings of cerebrospinal fluid(CSF) analysis, patients sometimes complain of headaches. Therefore, other pathways may contribute to the occurrence of headaches in aseptic meningitis or meningismus. We... |
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- The significance of vascular endothelial growth factor(VEGF) in children with asthma and pneumonia
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Seong Hwan Choi, Jung Yeon Shim, Myung Hwan Yoo, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
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Clin Exp Pediatr. 2006;49(2):192-197. Published online February 15, 2006
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Purpose : Vascular endothelial growth factor(VEGF) is a key cytokine for controlling vascular permeability and angiogenesis, which is one of the major findings in airway remodeling. However, it is not well known if it is associated with acute lower respiratory tract disease such as lobar pneumonia. The aim of this study is to compare serum VEGF levels in patients with... |
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- A clinical study of migraines without aura in children : based on revised international headache society criteria
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Bo Gil Seo, Myung Hwan Yoo, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-soo Kim
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Clin Exp Pediatr. 2006;49(1):71-75. Published online January 15, 2006
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Purpose : Because migraine in children has different characteristics from that in adults, it is inappropriate to apply migraine criteria for adults to children. Recently, the International Headache Society(IHS) revised criteria regarding children's characteristics. Therefore, we reviewed the characteristics of childhood migraines without auras based on the revised criteria and compared the data with the findings of childhood migraine by... |
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- Outcomes and Management of Fetal Infants with Birth Weight Below 500 g at a Tertiary Center
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Yun Sil Chang, Yu Jin Kim, Soo Hyun Koo, Jang Hoon Lee, Jong Hee Hwang, Chang Won Choi, Jae Won Shim, Sung Shin Kim, Sun Young Ko, Eun Kyung Lee, Won Soon Park
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Clin Exp Pediatr. 2005;48(9):939-945. Published online September 15, 2005
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Purpose : The purpose of this study was to report outcome of fetal infants with birth weight below 500 g known as lower limit of viability and to evaluate treatment characteristics and short-term morbidity of their survivors.
Methods : We retrospectively analyzed the medical records of all fetal infants with birth weight below 500 g who were delivered at Samsung Medical... |
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- Case Report
- Two Cases of Lead Poisoning due to Herb Medicinal Pills
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Seong Hwan Choi, Eun Young Park, Jung Yeon Shim, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
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Clin Exp Pediatr. 2005;48(9):1009-1015. Published online September 15, 2005
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We encountered two children with lead poisoning who were administered herb medicinal pills recommended by their clergyman. These patients presented anemia and severe coliky abdominal pain, but no neurologic symptoms. For this reason, they were initially misdiagnosed with gastrointestinal hemorrhagic disease. However, we got a clue that they took herb medicinal pills. Finally, based on the assay of blood lead... |
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- Original Article
- Clinical Significance of Immature Reticulocyte Fraction and Reticulocyte Cellular Indices in Pediatric Anemia Patients
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Young Seo, Hye Lim Jung, Jae Won Shim, Deok Su Kim, Jeong Yeon Shim, Moon Soo Park
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Clin Exp Pediatr. 2005;48(3):284-291. Published online March 15, 2005
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Purpose : Flow cytometric automated reticulocyte analysis is a superior method to manual reticulocyte counting, with respect to precision and sensitivity. Furthermore, flow cytometric analysis is able to measure immature reticulocyte fraction(IRF) and reticulocyte cellular indices(RCI : cell hemoglobin content : CHr, mean cell volume : MCVr, cell hemoglobin concentration mean : CHCMr, distribytion width : RDWr, HDWr, CHDWr). In... |
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- Evaluation of Serum Insulin-Like Growth Factor(IGF)-I, Insulin-Like Growth Factor Binding Protein(IGFBP)-2 and
IGFBP-3 Levels in Healthy Korean Children
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Gi Hoon Yang, Hye Lim Jung, Deok Soo Kim, Jae Won Shim, Jung Yeon Shim, Moon Soo Park
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Clin Exp Pediatr. 2005;48(3):298-305. Published online March 15, 2005
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Purpose : We performed this study to evaluate the mean serum levels of insulin-like growth factor (IGF)-I, insulin-like growth factor binding protein(IGFBP)-2 and IGFBP-3 in healthy Korean children according to age and sex.
Methods : Ninety two healthy children, consisting of 42 boys and 50 girls, were classified into five groups according to age : neonate; infancy; early childhood; late childhood;... |
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- Serum and Cerebrospinal Fluid(CSF) Nitric Oxide, Macrophage Inflammatory Protein-1α and Lactoferrin Levels in Aseptic Meningitis
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Young Seo, Jung Yeon Shim, Jae Won Shim, Deok Su Kim, Hye Lim Jung, Moon Soo Park
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Clin Exp Pediatr. 2005;48(1):48-54. Published online January 15, 2005
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Purpose : The pathologic mechanisms of central nervous system(CNS) injuries in human meningitis are not yet completely understood. Recent studies indicate that the host inflammatory responses are as important in brain damage as the infecting organisms and toxins. There have been some reports on the relationship of nitric oxide(NO), macrophage inflammatory protein-1α(MIP-1α), and lactoferrin in bacterial meningitis, but few reports... |
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- Serum Vascular Endothelial Growth Factor as a Predictive Risk Factor for the Occurrence of
Coronary Artery Lesions in Kawasaki Disease
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Min Hyuk Park, Hye Lim Jung, Ju Hee Yang, Jung-Yeon Shim, Deok Soo Kim, Jae Won Shim, Moon Soo Park
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Clin Exp Pediatr. 2003;46(8):811-816. Published online August 15, 2003
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Purpose : Kawasaki disease is an acute systemic vasculitis of unknown etiology with a predilection for the coronary arteries. Vascular endothelial growth factor(VEGF) is a cytokine which promotes vascular permeability and angiogenesis. We investigated serum VEGF(sVEGF) levels in Kawasaki disease to determine whether sVEGF level can be used as a risk factor to predict the occurrence of coronary artery lesions(CAL)... |
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- Change in the Limit of Viability of Fetal Infants
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Chang Won Choi, Jong Hee Hwang, Jae Won Shim, Sung Sin Kim, Sun Young Ko, Eun Kyung Lee, Yun Sil Chang, Won Soon Park
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Clin Exp Pediatr. 2003;46(12):1194-1199. Published online December 15, 2003
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Purpose : To determine the change in the limit of viability in fetal infants and the incidence of major complications in neonatal intensive care unit(NICU) at Samsung Medical Center(SMC).
Methods : Sevety-three infants weighing less than 800 g at birth and 117 infants born earlier than 27 weeks gestational age, who were admitted to NICU at SMC between November 1994... |
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- A Study of Vascular Reactivity Change in Nephrotic Syndrome Children Using Plethysmography
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Jae Won Shim, Byoung Hoon Yoo, In Suk Lim
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Clin Exp Pediatr. 1997;40(5):650-659. Published online May 15, 1997
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Purpose : The nephrotic syndrome is characterized by proteinuria, hypoproteinemia, edema and hyperlipidemia. These can change body homeostasis and cause hypertension. This study was designed to determine the relationship between the forearm vasodilating capacity and serum cholesterol level of nephrotic syndrome patients.
Methods : 15 Nephrotic syndrome patients and 17 normal control children who visited Chung-ang University Youngsan Hospital from Sep.... |
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